A1086
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A1086
Sigma
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
≥97% (HPLC), powder
| Synonym: | Ac-DEVD-AMC |
| CAS Number: | 169332-61-0 |
| Linear Formula: | C30H37N5O13 |
| Molecular Weight: | 675.64 |
| MDL number: | MFCD00671411 |
| PubChem Substance ID: | 24890505 |
Description
| Biochem/physiol Actions | Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. |
Properties
| assay | ≥97% (HPLC) |
| form | powder |
| composition | Peptide content, ~65% |
| color | white |
| solubility | DMSO: 10 mM |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
Related Products
| Related product | CASP3F, Caspase 3 Assay Kit, Fluorimetric |
References
| reference | Nicholson, D.W., Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37, (1995) |
| Marks, N., Activation of caspase-3 and apoptosis in cerebellar granule cells. J. Neurosci. Res. 52, 334, (1998) | |
| He, J., et al., Protease activation and cleavage of poly(ADP-ribose) polymerase: an integral part of apoptosis in response to photodynamic treatment. Cancer Res. 58, 940-946, (1998) | |
| Armstrong, R.C., et al., Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J. Neurosci. 17, 553-562, (1997) |
